Pharmaceuticals
Colloidal Anhydrous Silica Application In Pharmaceuticals
Colloidal anhydrous silica (Fumed silica), a highly versatile material, finds widespread applications as an excipient in the pharmaceutical industry. It effectively addresses challenges related to poor flowability of particles and powders, difficulties in tablet blending and compression, as well as aesthetic concerns. colloidal silicon dioxide offers several key functions and benefits, including:
- Improved Flowability:
- Enhances the flow characteristics of particles and powders during manufacturing processes.
- Ensures smooth and consistent production flow.
- Tablet Production:
- Acts as a lubricant and anti-adherent to prevent tablet sticking and ease tablet release from molds.
- Facilitates the production of well-formed tablets with precise dosing and appealing appearance.
- Emulsion and Suspension Stabilization:
- Functions as a stabilizer in milk-like emulsions and cloudy suspensions.
- Maintains formulation stability, preventing phase separation and ensuring uniform dispersion of active ingredients.
- Drug Carrier and Absorption Enhancement:
- Serves as a carrier for drugs, prolonging their efficacy.
- Facilitates drug absorption in the body, promoting enhanced therapeutic effects.
HIFULL® fumed silica imparts excellent performance to pharmaceutical products, offering the following key functionalities:
Applications & Advantages
Tablets
HIFULL’s fumed silica plays a crucial role in tablet production. Enhancing the flowability of dry powders as a flow aid, improves the efficiency of tablet manufacturing processes. The addition of colloidal silicon dioxide ensures uniformity and strength during tablet compression. Moreover, it enhances the free flow of powders and particles, facilitating smooth and consistent filling of capsules.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Ointments
Colloidal anhydrous silica is highly effective in ointment formulations. Its ability to absorb liquid active components allows for controlled release and optimal delivery of pharmaceutical ingredients onto the skin. The presence of colloidal silicon dioxide ensures a uniform and stable ointment consistency, even across a wide temperature range, providing enhanced efficacy and comfort during application.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Soft Gelatin Capsules
Colloidal anhydrous silica serves as a key ingredient in soft gelatin capsules, particularly for formulations with insoluble components. It provides anti-settling properties, preventing the settling of these components in liquid or gel formulations. This ensures the homogeneity and stability of the capsule contents, maintaining consistent quality throughout the product’s shelf life.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Gels and Semi-solid Formulations
In gel and semi-solid formulations, colloidal silicon dioxide acts as a versatile ingredient. It functions as a thixotropic thickening agent, imparting desirable texture and viscosity to the formulation. Additionally, it acts as a suspending aid, promoting the even dispersion and suspension of particles within the formulation. This helps prevent the formation of hard sedimentation and minimizes nozzle blockage in non-inhalation aerosols, ensuring smooth and uninterrupted application.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Suppositories with Lipophilic Matrices
Colloidal anhydrous silica finds application in suppository formulations containing lipophilic matrices. It increases the viscosity of the formulation, preventing the precipitation of active ingredients during the molding process. This ensures the integrity and stability of the suppository, allowing for controlled release and prolonged therapeutic effect.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Drugs such as Erythromycin
Colloidal anhydrous silica has the ability to modify the dissolution rates of certain drugs, such as erythromycin. By altering the dispersion and absorption properties of the drug in water, colloidal silicon dioxide can optimize its therapeutic performance, providing desired drug release profiles and enhancing patient outcomes.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Aspirin Powder
The addition of a small amount of Colloidal anhydrous silica to aspirin powder can significantly alter its anti-static properties. This helps to reduce electrostatic charges and improve powder handling, ensuring better flow and ease of processing during manufacturing operations.
| Application | Recommended Addition Level | Recommended Hydrophilic Product | Recommended Hydrophobic Product |
|---|---|---|---|
| Tablets | 0.50% | HIFULL HL-200 | HIFULL HB-151 |
Other Application
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