Pharmaceuticals

Pharmaceuticals

Colloidal Anhydrous Silica Application In Pharmaceuticals

Colloidal anhydrous silica (Fumed silica), a highly versatile material, finds widespread applications as an excipient in the pharmaceutical industry. It effectively addresses challenges related to poor flowability of particles and powders, difficulties in tablet blending and compression, as well as aesthetic concerns. colloidal silicon dioxide offers several key functions and benefits, including:

  1. Improved Flowability:
    • Enhances the flow characteristics of particles and powders during manufacturing processes.
    • Ensures smooth and consistent production flow.
  2. Tablet Production:
    • Acts as a lubricant and anti-adherent to prevent tablet sticking and ease tablet release from molds.
    • Facilitates the production of well-formed tablets with precise dosing and appealing appearance.
  3. Emulsion and Suspension Stabilization:
    • Functions as a stabilizer in milk-like emulsions and cloudy suspensions.
    • Maintains formulation stability, preventing phase separation and ensuring uniform dispersion of active ingredients.
  4. Drug Carrier and Absorption Enhancement:
    • Serves as a carrier for drugs, prolonging their efficacy.
    • Facilitates drug absorption in the body, promoting enhanced therapeutic effects.

HIFULL® fumed silica imparts excellent performance to pharmaceutical products, offering the following key functionalities:

  • Flow Aid: Improves the flowability of particles and powders, enhancing their ability to flow and be compressed.
  • Lubricant: Facilitates smooth tablet compression, aiding in uniform tablet feeding and achieving a glossy and appealing tablet surface.
  • Binder: Promotes cohesive bonding of pharmaceutical ingredients, facilitating easy tablet ejection and ensuring accurate dosage with a clean and attractive tablet surface.
  • Sustained Release Agent: Enables controlled release of drugs in the body, prolonging drug efficacy, extending drug action duration, and promoting drug absorption.
  • Disintegrant: Absorbs water and swells, causing the tablet’s binding forces to break, leading to fragmentation into smaller particles within the gastrointestinal tract, thus facilitating therapeutic effectiveness.

Applications & Advantages

Tablets

HIFULL’s fumed silica plays a crucial role in tablet production. Enhancing the flowability of dry powders as a flow aid, improves the efficiency of tablet manufacturing processes. The addition of colloidal silicon dioxide ensures uniformity and strength during tablet compression. Moreover, it enhances the free flow of powders and particles, facilitating smooth and consistent filling of capsules.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Ointments

Colloidal anhydrous silica is highly effective in ointment formulations. Its ability to absorb liquid active components allows for controlled release and optimal delivery of pharmaceutical ingredients onto the skin. The presence of colloidal silicon dioxide ensures a uniform and stable ointment consistency, even across a wide temperature range, providing enhanced efficacy and comfort during application.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Soft Gelatin Capsules

Colloidal anhydrous silica serves as a key ingredient in soft gelatin capsules, particularly for formulations with insoluble components. It provides anti-settling properties, preventing the settling of these components in liquid or gel formulations. This ensures the homogeneity and stability of the capsule contents, maintaining consistent quality throughout the product’s shelf life.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Gels and Semi-solid Formulations

In gel and semi-solid formulations, colloidal silicon dioxide acts as a versatile ingredient. It functions as a thixotropic thickening agent, imparting desirable texture and viscosity to the formulation. Additionally, it acts as a suspending aid, promoting the even dispersion and suspension of particles within the formulation. This helps prevent the formation of hard sedimentation and minimizes nozzle blockage in non-inhalation aerosols, ensuring smooth and uninterrupted application.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Suppositories with Lipophilic Matrices

Colloidal anhydrous silica finds application in suppository formulations containing lipophilic matrices. It increases the viscosity of the formulation, preventing the precipitation of active ingredients during the molding process. This ensures the integrity and stability of the suppository, allowing for controlled release and prolonged therapeutic effect.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Drugs such as Erythromycin

Colloidal anhydrous silica has the ability to modify the dissolution rates of certain drugs, such as erythromycin. By altering the dispersion and absorption properties of the drug in water, colloidal silicon dioxide can optimize its therapeutic performance, providing desired drug release profiles and enhancing patient outcomes.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Aspirin Powder

The addition of a small amount of Colloidal anhydrous silica to aspirin powder can significantly alter its anti-static properties. This helps to reduce electrostatic charges and improve powder handling, ensuring better flow and ease of processing during manufacturing operations.

ApplicationRecommended Addition LevelRecommended Hydrophilic ProductRecommended Hydrophobic Product
Tablets0.50%HIFULL HL-200HIFULL HB-151

Other Application

Hello, Customers

My name is Van, I’m the business manager of HIFULL, I have been in Fumed Silica Industry for more than 10 years. Feel free to contact me. I’m happy to provide you the best service and products.
Van
Business Manager